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Inflammatory Response / Sepsis · Observational Study
ClinicalTrials.gov · August 4, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a registry record for a recruiting, single-center observational study designed to correlate memory and effector CD8+ T cell subsets (Tcm and Tem) measured at multiple early timepoints with sepsis severity and mortality outcomes. No results have been reported; the study remains in recruitment phase and is preliminary.
Observational. Sepsis, Inflammatory Response; age from 18 Years; to 60 Years; accepts healthy volunteers. Intervention: septic patients; healthy control group. n = 80. 1 site: China.
This is a registry record for a recruiting, single-center observational study designed to correlate memory and effector CD8+ T cell subsets (Tcm and Tem) measured at multiple early timepoints with sepsis severity and mortality outcomes. No results have been reported; the study remains in recruitment phase and is preliminary.
Specific inclusion/exclusion criteria, sepsis definitions, and mortality ascertainment methods not provided in registry record.
Once results are published, this study may identify CD8+ T cell immunophenotypes that correlate with sepsis severity and mortality, potentially informing immune-based risk stratification or therapeutic targeting in acute sepsis. Clinicians should await outcome reporting before clinical application.
This is a recruiting observational study with no results posted; it aims to correlate memory CD8+ T cell subsets with sepsis outcomes but has not yet reported findings.
As stated by the source record.
Quoted from the source exactly as published.
Once results are published, this study may identify CD8+ T cell immunophenotypes that correlate with sepsis severity and mortality, potentially informing immune-based risk stratification or therapeutic targeting in acute sepsis. Clinicians should await outcome reporting before clinical application.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT05875740). This is a study registration, not published results. Lead sponsor: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology. Recruitment status: RECRUITING. Study type: OBSERVATIONAL. Enrollment: 80 participants (ESTIMATED). Conditions: Sepsis, Inflammatory Response. Primary outcome measures: Absolute number of CD8+T subsets in the peripheral blood (0 hour) , 0 hour after study inclusion; Absolute number of CD8+T subsets in the peripheral blood (24 hours) , 24 hours after study inclusion; Absolute number of CD8+T subsets in the peripheral blood (48 hours) , 48 hours after study inclusion; Absolute number of CD8+T subsets in the peripheral blood (72 hours) , 72 hours after study inclusion; proliferation of CD8+T subsets in the peripheral blood (0 hour) , 0 hour after study inclusion; proliferation of CD8+T subsets in the peripheral blood (24 hours) , 24 hours after study inclusion; proliferation of CD8+T subsets in the peripheral blood (48 hours) , 48 hours after study inclusion; proliferation of CD8+T subsets in the peripheral blood (72 hours) , 72 hours after study inclusion; ICU length of stay , up to 4 weeks; PD-1 expression of CD8+T subsets in the peripheral blood (24 hours) , 24 hours after study inclusion. Brief summary: Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated host response to infection. Severe sepsis is the most common cause of death among critically ill patients in non-coronary intensive care units (ICU). Sustained excessive inflammation and immune dysfunction have been confirmed to play a key role in organ damage and early death of sepsis patients. Therefore, it is important to reduce excessive inflammatory response mediated by immune cells and pro-inflammatory cytokines in the acute phase of sepsis. Single-cell RNA sequencing performed on both septic patients and mice suggest that changes in Tcm (CD3+ CD8+ CD44+ CD127+ CD62L+) and Tem (CD3+ CD8+ CD44+ CD127+ CD62L -) in the acute phase of sepsis may play an important role in sepsis. In addition, animal researches showed that Tcm and Tem decreased decreased continuously at 24, 48 and 72h after cecal ligation and perforation (CLP) in mice, and the adoptive transfer of Tcm , sorting from spleen of mice 24h after CLP , but not Tem improved 7-day survival rate of sepsis mice. This observational study is aimed to investigate the quantity and proliferation of Tcm and Tem in the acute phase of sepsis and their correlation with severity level and mortality of septic patients in ICU.
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