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Life sciences · Journal article
Ip Indian Journal of Clinical and Experimental Dermatology · September 28, 2026
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Background: Chronic Spontaneous Urticaria (CSU) is increasingly regarded as a systemic inflammatory disease, possibly related with metabolic abnormalities. The present study aims to investigate the prevalence of Metabolic Syndrome (MetS) in patients with CSU in comparison with healthy controls and to evaluate the association of metabolic parameters with standard laboratory markers including C-reactive protein (CRP) and Thyroid Stimulating Hormone (TSH).Materials and Methods: This cross sectional study included 300 participants; 150 patients with CSU and 150 age and sex matched healthy controls. Metabolic syndrome was diagnosed based on the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria. Anthropometric measurements were taken from the individuals and fasting blood glucose and lipid profiles were measured.Results: The prevalence of MetS was substantially greater in the CSU group (32.0%) than in the control group (16.0%) (p < 0.001). Mean levels of triglycerides and fasting plasma glucose were significantly elevated while mean levels of HDL cholesterol were dramatically decreased in CSU patients. The most prevalent metabolic anomaly was central obesity, which affected 42.7% of CSU patients. Mean CSU disease duration was substantially longer in patients with MetS (20.5 months, p < 0.004) than in those without MetS (11.2 months, p < 0.016). In addition, high CRP levels were significantly related with metabolic syndrome in the CSU population.Conclusion: There is an association between CSU and Metabolic Syndrome. Metabolic risk factors should be often screened in chronic diseases and in patients with systemic inflammation. This study highlights metabolic risk assessment in Chronic Spontaneous Urticaria patients, promoting SDG 3: Good Health and Well-Being. Early diagnosis of associated conditions such as Metabolic Syndrome can enhance prevention and decrease of non-communicable diseases.