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Life sciences · Observational Study
ClinicalTrials.gov · September 21, 2026
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Observational Study.
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Registry record from ClinicalTrials.gov (NCT05992558). This is a study registration, not published results. Lead sponsor: Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal. Recruitment status: COMPLETED. Study type: OBSERVATIONAL. Enrollment: 175 participants (ACTUAL). Conditions: Heart Failure With Preserved Ejection Fraction. Primary outcome measures: Composite of 1-year all-cause mortality and/or HF-hospitalization , 12 months. Brief summary: The goal of this observational study is to develop longitudinal multimarker risk models for decision support during the clinical follow-up of very elderly patients with heart failure and preserved ejection fraction (HFpEF). The main questions it aims to answer are: * Can advanced risk prediction models accurately estimate the prognosis of very elderly patients with HFpEF over a 1-year follow-up after a hospitalization for acute heart failure? * Do novel biomarkers, in addition to routine clinical variables and elderly-specific predictors, contribute to improved risk prediction for these patients? To this end, very elderly patients (aged 80 or older) who have HFpEF and were admitted for acute heart failure will be included. Clinical and biological data will be collected during their hospitalization and also during follow-up visits 30 and 90 days after discharge. There is no comparison group in this observational study.