Loading
Life sciences · Journal article
Archives of Plastic Surgery · September 17, 2026
No summary has been generated for this record yet. What follows is drawn from its source metadata only.
Journal article.
No findings were extractable from the material analysed.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
This record has not been graded across any dimension yet. Treat the label above as provisional and read the source.
What is missing. This record has no bottom line, key findings, reported figures, evidence dimensions. That is a gap in the analysis, not a judgement about the study.
Background: For patients receiving immunotherapies and anti-neoplastic agents, understanding the implications of medication effects on wound healing is critical for surgical planning. With the advent of new oncologic and immune therapies, plastic surgeons are faced with unfamiliar therapies among patients seeking reconstructive or aesthetic surgery. The of this study is to provide an evidence-based, structured narrative review of the effects of common anti-neoplastic and immune modulatory medications on wound healing to elucidate key clinical considerations for surgical planning. Methods: Searches utilizing various indexing terms and key words surrounding wound healing, antineoplastic agents, and immunotherapies was conducted with PubMed and Embase by Elsevier. The search was limited to full text, non-review articles in English published between 2002 and 2023. Articles were screened independently by five investigators. Case reports, randomized control trials, prospective cohort studies, or retrospective cohort studies that investigated an antineoplastic agent and reported on outcomes related to wound healing were included. Articles were excluded if they reported on animals, analgesics, steroids, or did not investigate outcomes related to wound healing. Results: Screening yielded 45 articles for analysis. Drug categories included checkpoint inhibitors, mammalian target of rapamycin inhibitors, alkylating agents, antimetabolites, monoclonal antibodies, and tyrosine kinase inhibitors, and receptor tyrosine kinase inhibitors. Many postoperative surgical wound healing complications were documented across classes. Conclusion: Our study provides a review of wound healing complications associated with anti-neoplastic agents and immunotherapies. Application of this review in the context of expanding medical treatment for cancer, has high importance to wound healing in plastic surgery.