Loading
Life sciences · Journal article
Journal of Agricultural and Food Chemistry · October 10, 2026
No summary has been generated for this record yet. What follows is drawn from its source metadata only.
Journal article.
No findings were extractable from the material analysed.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
This record has not been graded across any dimension yet. Treat the label above as provisional and read the source.
What is missing. This record has no bottom line, key findings, reported figures, evidence dimensions. That is a gap in the analysis, not a judgement about the study.
Abstract The role of probiotics in weight management remains controversial. In this study, we found that Lactobacillus gasseri LG-G12 exhibits gut colonization capacity and metabolic regulation potential in vitro. In vivo, LG-G12 alleviated high-fat diet-induced weight gain and visceral fat accumulation in mice. Fecal targeted metabolomics identified bile acid metabolism as a key pathway. Furthermore, LG-G12 might exhibit bile salt hydrolase and hydroxysteroid dehydrogenase activities, contributing to a bile acid profile characterized by low cholic acid and high ursodeoxycholic acid levels. Additionally, LG-G12 increased the abundance of deoxycholic acid-producing Eubacterium spp., leading to elevated DCA levels. This distinct bile acid profile activated FXR and TGR5, reducing lipid accumulation and adipocyte differentiation in the liver and epididymal adipose tissue, and promoting thermogenesis in brown adipose tissue. Collectively, these findings demonstrate that LG-G12 ameliorates high-fat diet-induced obesity via the gut microbiota-bile acid axis, positioning LG-G12 as a promising candidate for weight management.