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atrioventricular node ablation / Atrial Fibrillation, Persistent / pacemaker implantation · Interventional Study
ClinicalTrials.gov · September 11, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a planned randomized trial comparing atrioventricular node ablation with conduction system pacing against optimal medical rate control in patients with HFpEF and persistent atrial fibrillation. No results are yet reported; the study is actively recruiting and will follow participants for 24 months to assess impact on mortality and heart failure hospitalizations.
Interventional, Randomized, Parallel, Single masking, Treatment purpose. Heart Failure With Preserved Ejection Fraction, Atrial Fibrillation, Persistent; age from 18 Years. Intervention: Intervention group with pacemaker implantation and atrioven…. Compared with: Control — No Intervention. n = 266. 17 sites: France.
This is a planned randomized trial comparing atrioventricular node ablation with conduction system pacing against optimal medical rate control in patients with HFpEF and persistent atrial fibrillation. No results are yet reported; the study is actively recruiting and will follow participants for 24 months to assess impact on mortality and heart failure hospitalizations.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
This is a clinical trial registry record describing a planned interventional study with no results reported; enrollment is ongoing and primary outcome data collection extends to 24 months.
As stated by the source record.
Quoted from the source exactly as published.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT06833138). This is a study registration, not published results. Lead sponsor: French Cardiology Society. Recruitment status: RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 266 participants (ESTIMATED). Conditions: Heart Failure With Preserved Ejection Fraction, Atrial Fibrillation, Persistent. Interventions: PROCEDURE: pacemaker implantation; PROCEDURE: atrioventricular node ablation; DEVICE: Pacemaker programming. Primary outcome measures: Time to the composite of all-cause mortality or hospitalization due to heart failure or intravenous diuretics. , 24 months. Brief summary: The goal of this clinical trial is to assess the clinical efficacy of physiological pacing combined with atrioventricular node ablation, in patients with Heart Failure with preserved Ejection Fraction (HFpEF) and well controlled permanent atrial fibrillation.The main question it aims to answer is that heart rate regularization added to physiological pacing - preventing the deleterious effect of right ventricular apical pacing - would reduce mortality and heart failure hospitalizations. Researchers will compare physiological pacing combined with atrioventricular node ablation (intervention arm) versus optimal pharmacological therapy (control arm) to see if physiological pacing combined with atrioventricular node ablation reduce time to the composite of all-cause mortality or hospitalization due to heart failure or intravenous diuretics (time frame 24 months). Participants will : * Be randomized in intervention arm or control arm. * Visit the clinic 3 months, 12 months and 24 months after the randomization for checkups and tests.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.