Life sciences · Preprint
arXiv · September 28, 2026
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We introduce the Functional Spectral-Newton Method (FSNM) for learning the leading singular structure of a conditional expectation operator without fixing a basis or reproducing kernel Hilbert space. FSNM fits a low-rank representation of the centered joint-to-product density ratio kernel by alternating functional Newton updates. Each update reduces to a preconditioned regression, which we approximate with vector-valued regression trees in a stagewise boosting procedure. At the population level, we establish descent and an $O(1/T)$ best-iterate block-stationarity rate under a relative weak-learner accuracy condition, and show that every nondegenerate local minimum over the full centered $L^2$ spaces is a globally optimal rank-$d$ approximation. Synthetic experiments show that FSNM recovers a low-rank density ratio and its leading spectral structure, and that the same learned kernel can answer multiple conditional queries without refitting.