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CanCOG® - Cogntive Rehabilitation in Cancer / Cancer Related Cognitive Dysfunction / Cancer Related Cognitive Difficulties · Interventional Study
ClinicalTrials.gov · August 10, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a registry record for a pilot randomized trial of CanCOG®, a six-week cognitive rehabilitation program for cancer survivors with cancer-related cognitive impairment. The study is not yet recruiting and no results are available. The trial is designed primarily to assess feasibility, acceptability, and process outcomes, with exploratory efficacy measures on cognitive function, mood, and quality of life.
Interventional, Randomized, Parallel, Open label, Treatment purpose. Cancer-related Cognitive Impairment, Cancer-related Cognitive Dysfunction, Cancer-related Cognitive Difficulties, Depression and Anxiety Symptoms, Quality of L…; age from 18 Years; to 65 Years. Intervention: Cognitive rehabilitation intervention. Compared with: Treatment-as-usual — No Intervention. n = 60. 1 site: Portugal.
This is a registry record for a pilot randomized trial of CanCOG®, a six-week cognitive rehabilitation program for cancer survivors with cancer-related cognitive impairment. The study is not yet recruiting and no results are available. The trial is designed primarily to assess feasibility, acceptability, and process outcomes, with exploratory efficacy measures on cognitive function, mood, and quality of life.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
Results are not yet available. When completed, this pilot will inform feasibility and acceptability of a cognitive rehabilitation program; if positive, it may support design of a larger efficacy trial, but cannot alone establish clinical benefit.
This is a pilot feasibility and acceptability trial not yet recruiting, with no results posted; it measures process outcomes and explores preliminary efficacy signals in cancer-related cognitive impairment.
As stated by the source record.
Quoted from the source exactly as published.
Results are not yet available. When completed, this pilot will inform feasibility and acceptability of a cognitive rehabilitation program; if positive, it may support design of a larger efficacy trial, but cannot alone establish clinical benefit.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT07755839). This is a study registration, not published results. Lead sponsor: Aveiro University. Recruitment status: NOT_YET_RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 60 participants (ESTIMATED). Conditions: Cancer-related Cognitive Impairment, Cancer-related Cognitive Dysfunction, Cancer-related Cognitive Difficulties, Depression and Anxiety Symptoms, Quality of Life. Interventions: BEHAVIORAL: CanCOG® - Cogntive Rehabilitation in Cancer. Primary outcome measures: Feasibility - Screening rate , Baseline (2 weeks before intervention), post-intervention (2 weeks after), and 3-month and 6-month follow-ups.; Feasibility - Eligibility rate , Baseline (2 weeks before intervention), post-intervention (2 weeks after), and 3-month and 6-month follow-ups; Feasibility - Consent rate , Baseline (2 weeks before intervention), post-intervention (2 weeks after), and 3-month and 6-month follow-ups.; Feasibility - Retention rate , Baseline (2 weeks before intervention), post-intervention (2 weeks after), and 3-month and 6-month follow-ups; Feasibility - Assesment completion rate , Baseline (2 weeks before intervention), post-intervention (2 weeks after), and 3-month and 6-month follow-ups; Feasibility - Intervention adherence , Baseline (2 weeks before intervention), post-intervention (2 weeks after), and 3-month and 6-month follow-ups; Feasibility - Intervention fidelity , Baseline (2 weeks before intervention), post-intervention (2 weeks after), and 3-month and 6-month follow-ups; Acceptability - Participant retention and intervention adherence , Baseline ( 2 weeks before intervention), post-intervention (2 weeks after), and 3-month and 6-month follow-up.; Acceptability - Qualitative feedback , Post-intervention (2 weeks after); Acceptability - ACRIS-CS , Baseline (2 weeks before intervention) and post-intervention (2 weeks after).. Brief summary: Cancer-related cognitive impairment (CRCI) affects a large proportion of non-central nervous system cancer survivors and can negatively impact cognitive functioning and daily life. Cognitive rehabilitation has shown promising results in addressing these difficulties. The goal of this pilot randomized controlled trial is to evaluate the feasibility, acceptability, and preliminary efficacy of the CanCOG®- Cognitive Rehabilitation in Cancer program in Portuguese adult cancer survivors with CRCI. Adult non-central nervous system cancer survivors (n=60) will be randomly assigned to receive either the CanCOG® intervention or treatment as usual. CanCOG® is a structured cognitive rehabilitation program designed to help cancer survivors manage cognitive difficulties through cognitive training exercises, psychoeducation, and compensatory strategy training. The program consists of six weekly sessions of 1 hour and 30 minutes each, delivered over six consecutive weeks. Sessions are administered in person in small groups (3-9 participants) and are led by a trained professional. The main focus of the study is to assess feasibility outcomes, including recruitment, retention, adherence to the intervention, and completion of study assessments, as well as acceptability and participant satisfaction. The study will also explore preliminary effects of the intervention on cognitive functioning (both perceived and objective), symptoms of anxiety and depression, and quality of life. Participants will complete assessments at baseline (2 weeks after the intervention), 2 weeks after the intervention, and at 3- and 6-month follow-ups. Some participants (10-15) will also take part in interviews to provide feedback on their experience with the program.
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