Loading
Life sciences · Journal article
Head & Neck · November 5, 2026
No summary has been generated for this record yet. What follows is drawn from its source metadata only.
Journal article.
No findings were extractable from the material analysed.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
This record has not been graded across any dimension yet. Treat the label above as provisional and read the source.
What is missing. This record has no bottom line, key findings, reported figures, evidence dimensions. That is a gap in the analysis, not a judgement about the study.
BACKGROUND: Perineural spread (PNS) in head and neck cancer (HNC) is technically challenging due to complex target volumes adjacent to critical organs. Data on stereotactic body radiation therapy (SBRT) for PNS is scarce. METHODS: This retrospective study included patients treated with SBRT for PNS across two centers in the USA and Canada from 2015 to 2025. Endpoints included overall survival (OS), progression-free survival (PFS), local control (LC), and treatment-related toxicity. RESULTS: Thirty-six patients were included, with median follow up of 47.5 months. Two-year OS, PFS, and LC were 79%, 54%, and 72% respectively. Patients with cutaneous squamous cell carcinoma (cSCC) had superior PFS and LC compared with non-cSCC histologies. Adenoid cystic carcinoma (ACC) accounted for the only in-field failures. Grade ≥ 3 toxicity occurred in 22% (8/36), including grade ≥ 3 osteoradionecrosis in 6% (2/36). Temporal lobe necrosis was solely Grade 1-2 (32%). CONCLUSIONS: SBRT demonstrated durable LC for selected patients with PNS, particularly cSCC, while ACC may warrant a dose-escalated approach.