Asthma · Observational Study

Severe Asthma Research Program

ClinicalTrials.gov · August 14, 2026

Preliminary Why this matters to you Expert discussion

Early or partial results. Treat as a signal, not a conclusion.

AI Summary

This is a completed observational registry of 1100 participants with severe asthma, designed to characterise clinical and biological features and their changes over 36 months. No results are reported in this registry record; the study's findings remain unpublished.

What was studied

Observational. Asthma; age from 6 Years; accepts healthy volunteers. Intervention: Asthmatics; Healthy Controls. n = 1,100. 8 sites: United States.

Key findings

Safety

Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.

Who this may help

The source did not state who this applies to in practice.

Plain-language summary

This is a completed observational registry study with no results posted; it describes planned enrollment and primary outcome measures only, without reported findings.

Study design

As stated by the source record.

MethodsCohort model. Prospective time perspective. Primary outcome measure: Pulmonary function test results (assessed at 36 months after enrollment)

DesignObservational

PopulationAsthma; age from 6 Years; accepts healthy volunteers

Sample size1,100

InterventionAsthmatics; Healthy Controls

Setting8 sites: United States

Reported figures

Quoted from the source exactly as published.

Sample size (estimated enrollment)1100

Primary outcome measurePulmonary function test results at 36 months after enrollment

Study typeObservational

Caveats

Results are not reported in this registry record; outcomes remain unpublished.
Enrollment is estimated rather than final; actual sample may differ.
No data on retention, loss to follow-up, or analytical approach provided.
No comparator group or control arm described; findings will be descriptive only.

Evidence assessment

Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.

Study design

moderate

Observational design; no control group or randomization described.

Directness

moderate

Clinical outcome (pulmonary function) measured but no comparative effectiveness reported.

Consistency

insufficient

Registry record only; no results posted for comparison to other studies.

Risk of bias

insufficient

No methodology details on blinding, confounding control, or loss to follow-up.

Sample adequacy

moderate

1100 estimated participants; adequate size for observational work but enrollment is estimated.

What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.

Source abstract

Registry record from ClinicalTrials.gov (NCT01606826). This is a study registration, not published results. Lead sponsor: Milton S. Hershey Medical Center. Recruitment status: COMPLETED. Study type: OBSERVATIONAL. Enrollment: 1100 participants (ESTIMATED). Conditions: Asthma. Primary outcome measures: Pulmonary function test results , 36 months after enrollment. Brief summary: The mission of the SARP is to improve the understanding of severe asthma through integrated study of its clinical and biological features and to evaluate their changes over time. The ultimate goal of these efforts is to promote better treatments for severe asthma.

Follow from this

Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.

AsthmaNCT01606826Milton S. Hershey Medical Center