Loading
Life sciences · Preprint
arXiv · September 15, 2026
No summary has been generated for this record yet. What follows is drawn from its source metadata only.
Preprint.
No findings were extractable from the material analysed.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
This record has not been graded across any dimension yet. Treat the label above as provisional and read the source.
What is missing. This record has no bottom line, key findings, reported figures, evidence dimensions. That is a gap in the analysis, not a judgement about the study.
Approximating the input-output behavior of a multivariable black-box function from limited data is challenging when blind to the importance of its inputs and their interactions. We introduce total sensitivity kernels (TSKs), a method based on families of weighted ANOVA kernels that learn and adapt to this multivariable structure. TSKs parameterize the weights on each multivariable component of the target function by factors for each input. We propose learning these factors directly from function evaluations by selecting the reproducing kernel Hilbert space (RKHS) in which the target function has minimum norm. Under suitable conditions, we show that this norm-minimization problem admits a unique solution, and we establish consistency of a finite-data formulation based on minimum-norm interpolation. The learned TSK factors characterize the participation of individual inputs across interactions and main effects, providing a kernel-dependent notion of input sensitivity related to total Sobol indices. Numerical experiments demonstrate that adapting the kernel to learned multivariable structure can substantially improve approximation accuracy over a standard product kernel.