Loading
Life sciences · Journal article
Celal Bayar Üniversitesi Fen Bilimleri Dergisi · September 30, 2026
No summary has been generated for this record yet. What follows is drawn from its source metadata only.
Journal article.
No findings were extractable from the material analysed.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
This record has not been graded across any dimension yet. Treat the label above as provisional and read the source.
What is missing. This record has no bottom line, key findings, reported figures, evidence dimensions. That is a gap in the analysis, not a judgement about the study.
Thymoquinone (TQ), a bioactive compound derived from Nigella sativa, exhibits strong anticancer activity; however, its clinical application is limited by poor aqueous solubility and low bioavailability. In this study, an alginate-coated poly(lactic-co-glycolic acid) (PLGA) nanoparticle system was developed to improve TQ stability and provide controlled release. Nanoparticles were prepared by nanoprecipitation and characterized in terms of encapsulation efficiency, particle size, polydispersity index (PDI), zeta potential, and morphology using FTIR, SEM, and TEM. TQ quantification and release studies were performed by HPLC. The optimized nanoparticles showed a mean particle size of 178.1 ± 1.41 nm, encapsulation efficiency of 75.9 ± 0.75%, PDI of 0.4, and zeta potential of −25.55 mV. After 72 h, cumulative TQ release reached 81.7% at pH 5.5 and 75.7% at pH 7.4, indicating pH-responsive release behavior. Overall, the alginate-coated PLGA nanoparticles demonstrated potential as a controlled TQ delivery system for cancer therapy.