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Life sciences · Interventional Study
ClinicalTrials.gov · October 30, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT04389437). This is a study registration, not published results. Lead sponsor: Fondation Ophtalmologique Adolphe de Rothschild. Recruitment status: RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 450 participants (ESTIMATED). Conditions: Amnesia, Alzheimer Disease, Lewy Body Disease, Parkinsons Disease With Dementia. Interventions: PROCEDURE: Ophthalmological exam; PROCEDURE: Blood pressure measurement. Primary outcome measures: Wall to lumen ratio (WLR) , Baseline (Inclusion). Brief summary: Studies suggest an association between retinal abnormalities and NCD (Neuro Cognitive Disorders) whether they are linked to proven or prodromal Alzheimer's disease (aMCI : amnestic mild cognitive impairment), or to other neurodegenerative diseases such as frontotemporal dementia or Lewy body diseases. These retinal anomalies objectified by OCT-A (Optical coherence tomography angiography) and adaptive optics (AO) appear different depending on the pathologies and could therefore serve as markers in vivo of the pathophysiological processes underlying NCD. No study to date has studied the retina and its vessels in NCD using adaptive optics. In this pilot study, we are proposing a combination of two new ophthalmological imaging techniques (OCT-A and AO), which allow rapid in vivo analysis in a completely non-invasive way of the morphology of small vessels as well as architecture of the retina to better specify the retinal anomalies associated with NCD. We will compare the parameters in OCT-A and AO between patients with NCD and controls without NCD (with memory complaint or without) and will seek to determine if there are different profiles according to the causes of NCD.