Loading
Life sciences · Journal article
Osteoarthritis and Cartilage Open · August 22, 2026
No summary has been generated for this record yet. What follows is drawn from its source metadata only.
Journal article.
No findings were extractable from the material analysed.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
This record has not been graded across any dimension yet. Treat the label above as provisional and read the source.
What is missing. This record has no bottom line, key findings, reported figures, evidence dimensions. That is a gap in the analysis, not a judgement about the study.
Objective. Glenohumeral osteoarthritis (OA) is a leading cause of disabling shoulder pain, but little is known about glenohumeral OA risk factors. In the UK Biobank, we identified factors associated with OA-related shoulder arthroplasty (OA SA), as a measure of end-stage glenohumeral OA.Design. The UK Biobank collects extensive baseline survey data and follow-up through linked hospital records. OA SA was defined as presence of a SA procedure code with an OA diagnosis. Associations between each potential risk factor and OA SA were estimated with multivariable Cox regression. Identified risk factors were also evaluated with OA-related THA/TKA to compare the magnitude of associations across joints.Results. Among 494,203 people, there were 652 OA SA cases. Each decade increase in age was associated with more than twice the OA SA risk (Hazard ratio [HR] = 2.38, 95%CI = 2.04-2.76). Higher body mass index (BMI) was strongly associated with higher risk (HR for obese vs. healthy BMI = 3.08, 95%CI = 2.47-3.84). BMI associations were weaker for THA and stronger for TKA. OA SA risk increased consistently with increasing manual work frequency. Vigorous physical activity was only associated with elevated risk at the highest levels. The highest levels of manual work and physical activity were more strongly associated with OA SA than THA/TKA.Conclusions. Similar factors may drive OA in the shoulder as do the knee and hip, but the magnitude of associations differed by joint. Importantly, some of these factors could be amenable to intervention, such as better job design to reduce upper extremity burdens and weight loss programs to reduce obesity.