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Life sciences · Preprint
arXiv · October 7, 2026
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Language-model agents are increasingly asked to carry out open-ended scientific research, yet their results are usually graded against a known answer, a rubric, or a language-model reviewer, none of which can tell whether a new scientific model is valid. The AI Science Exam for El Nino-Southern Oscillation (SciExam for ENSO) is a benchmark in which agents build low-order stochastic models of ENSO, the dominant mode of interannual climate variability, from real observations. Within a six-hour budget, agents process the observations, write their own diagnostics, which are then frozen, and develop a model using only these diagnostics as feedback. Hidden graders then test whether the model reproduces ENSO's statistics, recovers unobserved variables, and forecasts held-out years, and score a published model in the same way. Across twelve agent systems, six produce models that score higher than the published model, mainly through better reconstruction and forecasting. The simplified forms of the stronger models are each compatible with one of the two competing explanations of ENSO's warm-cold asymmetry, an open debate that the task never mentions. Controlled runs of the top system under varied information suggest that its scores do not come from recalling the dated observational record and that the information it receives shapes how it builds its model. SciExam for ENSO can thus evaluate agent research where no answer is known, and the results suggest that agents can already build competitive models whose structures bear on questions that scientists still debate.