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Life sciences · Preprint
arXiv · November 7, 2026
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We present a novel GPU-accelerated global solver for constrained nonlinear programming (NLP) inspired by the efficient linear bound propagation framework in neural network (NN) verification. Existing work on NN verification, a problem that can be cast as feasibility detection for a nonlinear objective, demonstrated orders-of-magnitude speedups with the linear bound propagation-based framework when compared to traditional solvers. Extending this paradigm to global nonlinear programming requires addressing many challenges: a global constrained NLP solver must effectively exploit all, possibly unstructured, nonlinear constraints to improve the objective, whereas NN verification typically handles simple input box constraints over a well-structured NN and does not directly optimize an objective function. We address these challenges by fully exploiting the linear bounds produced by bound propagation: these linear bounds can be viewed as relaxations of nonlinear constraints and used to provide lower bounds, check infeasibility, and guide the search for a primal solution. In addition, we propose tighter linear relaxations for bilinear, quotient, and other commonly used nonlinear functions in NLP problems, and a projected augmented Lagrangian method tightly coupled to our dual solving procedure to produce primal solutions. Our method solves 421 of 505 bounded and continuous NLP problems in the GAMS and MINLPLib benchmarks under a 180-second limit, more than each of the six global solvers we compare with, including Gurobi and BARON (commercial), and SCIP (open-source). Sixteen of these problems are certified by none of the six global solvers; all of them contain exponential, logarithmic, or trigonometric terms, which are often challenging for traditional approaches. Project webpage is at https://verified-intelligence.github.io/GEAR.