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Life sciences · Journal article
Research Journal of Biotechnology · October 31, 2026
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Tomato (Lycopersicon esculentum L.) is a significant global crop, both from a nutritional and economic perspective. Tomato is widely cultivated, but its production is subjected to several stresses including bacterial canker disease caused by Clavibacter michiganensis subsp. michiganensis. This pathogen is a threat to tomato production and causes yield losses of 10% to 100%. The disease is sustained by its seedborne nature, ecological resilience and the absence of resistant commercial cultivars. Conventional management strategies involve the use of certified disease-free seeds, hot water or chemical seed therapies, crop rotation, sanitation and the application of chemical or biological controls. However, these approaches are inadequate and insufficient and the polygenic characteristics of resistance in tomatoes makes resistance breeding difficult. Promising options for improving disease resistance involve CRISPR-Cas9 genome editing. Editing diseaserelated genes including the PR-1A gene, showed potential for the development of tomato cultivars with improved tolerance of bacterial cankers and other pathogens. CRISPR technology allows for precise, heritable modifications that speed up the development of resistant lines and reduce reliance on chemical pesticides. But there are still hurdles such as the potential for off-target effects, regulatory complexity and public acceptance. The future of sustainable tomato production depends on the amalgamation of genome editing tools and enabling regulatory frameworks to ensure global food security.