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Life sciences · Journal article
International Journal of Statistics in Medical Research · September 29, 2026
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Geriatric Dry Eye Disease (DED) represents an escalating global public health challenge; yet traditional literature remains dominated by qualitative clinical narratives that lack macro-level structural synthesis. This study addresses this research gap by conducting a rigorous, quantitative bibliometric and computational network analysis mapping the global scientific landscape of geriatric DED from 2000 through 2026. Applying a strict PRISMA systematic review workflow across PubMed, Scopus, and the Web of Science Core Collection, a refined dataset of 105 core empirical studies was extracted and evaluated using R-Bibliometric and VOSviewer software parameters. Descriptive bibliometric analysis documents a clear exponential expansion in annual publication volume over the last decade, driven by East Asian and North American research networks. Algorithmic keyword co-occurrence parsing isolated four prominent thematic research clusters linking ophthalmic epidemiology, network indicators, targeted anti-inflammatory pharmacology, and patient-reported quality-of-life (QoL) outcomes. Pooled demographic sub-cohort evaluation demonstrates significant prevalence heterogeneity across high-risk groups, ranging from a baseline value of 22.4% in the general elderly population to an escalated rate of 74.2% in Sjögren’s syndrome subsets. Furthermore, structural interventional analysis charts a clear evolutionary shift from conventional, palliative surface lubrication toward target-specific anti-inflammatory molecules, advanced gene carriers, and automated device-driven therapies like Intense Pulsed Light. By integrating complex geriatric covariates—including polypharmacy, sleep disruptions, and cognitive decline into a unified epidemiological framework, this study delivers a reproducible, data-driven framework. Ultimately, these quantitative insights offer a vital predictive baseline for optimizing healthcare resource allocation, defining clinical practice protocols, and implementing automated screening models within ageing global societies.