Life sciences · Phase 2 Trial
ClinicalTrials.gov · September 16, 2026
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Phase 2 Trial.
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Registry record from ClinicalTrials.gov (NCT07823452). This is a study registration, not published results. Lead sponsor: Indiana University. Recruitment status: NOT_YET_RECRUITING. Phase: PHASE2. Study type: INTERVENTIONAL. Enrollment: 62 participants (ESTIMATED). Conditions: Obesity & Overweight. Interventions: DRUG: gut-brain axis (GLP-1)-activating food carbohydrate; OTHER: starch-based placebo control (commercial maltodextrin). Primary outcome measures: Serum GLP-1 level effect on satiation and caloric intake , 2 months; Changes in score on the Intuitive Eating Scale for Early Adolescents , 2 months; Changes in caloric intake , 2 months. Brief summary: Glucagon-like peptide (GLP1) drugs have quickly become a standard treatment for the adults with obesity. These drugs target the appetite control center of the brain, which clows the rate of stomach emptying, and makes a person feel full. The researchers are exploring this response in children. This study is being conducted to better understand how two food carbohydrates affect the appetite control center of the brain. The investigators want to see if a special carbohydrate powder that is mixed with 1 cup of water twice a day will appetite.