Loading
Life sciences · Journal article
Diabetology & Metabolic Syndrome · October 15, 2026
No summary has been generated for this record yet. What follows is drawn from its source metadata only.
Journal article.
No findings were extractable from the material analysed.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
This record has not been graded across any dimension yet. Treat the label above as provisional and read the source.
What is missing. This record has no bottom line, key findings, reported figures, evidence dimensions. That is a gap in the analysis, not a judgement about the study.
To identify circulating microRNA (miRNA) signatures associated with metabolic health status independent of body mass index (BMI) and to characterize their underlying regulatory pathways. Plasma samples from 240 Qatari adults were classified as metabolically healthy people with obesity (MHO), metabolically unhealthy people with obesity (MUHO), metabolically healthy normal-weight (MHNW), or metabolically unhealthy normal-weight (MUHNW) (n = 60/group). Differential miRNA expression was assessed using chemometric analyses, followed by target-gene and pathway enrichment analyses. Distinct circulating miRNA profiles differentiated metabolic phenotypes. Key miRNAs distinguishing MHO from MUHO included hsa-miR-122-5p, hsa-miR-195-5p, among others, differentiated MHNW from MUHNW. Predicted targets of MUHO-associated miRNAs were enriched in pathways related to lipid metabolism, insulin signaling, inflammation, oxidative stress, and apoptosis. In contrast, MUHNW-associated miRNAs were linked to immune regulation, inflammatory signaling, leukocyte migration, and lipid transport. Several miRNAs and miRNA ratios showed strong discriminatory performance across metabolic phenotypes. Circulating miRNA signatures distinguish metabolic health phenotypes independent of BMI and highlight distinct molecular pathways associated with metabolic dysfunction in people with obesity and normal weight.