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Diabetes, Cardiovascular Risks, and Lipoproteins · Journal article
Frontiers in Cardiovascular Medicine · August 12, 2026
Encouraging direction, but not yet definitive.
This retrospective study of 738 post-PCI AMI patients reports that TyG-WHtR is an independent predictor of 1-year HF occurrence (adjusted OR 1.192, 95% CI 1.021–1.392, p=0.026), with moderate discrimination (AUC 0.769) that exceeds related metabolic indices and GRACE score in HFpEF subgroups. The finding is clinically plausible but limited by retrospective methodology, single-centre design, and lack of prospective external validation.
Retrospective cohort study. Patients with acute myocardial infarction treated with percutaneous coronary intervention; setting and specific eligibility criteria not detailed in abstract.. Intervention: Baseline TyG-WHtR measurement (composite metabolic-obesity index calculated pre-discharge).. Compared with: GRACE score, TyG-WC, TyG-BMI, and standard HF risk factors.. n = 738. Not stated in source..
136 of 738 patients (18.4%) developed HF within 1-year follow-up. TyG-WHtR independent predictor of AMI-HF: adjusted OR=1.192 (95% CI 1.021–1.392, p=0.026). TyG-WHtR discrimination: AUC=0.769 (95% CI 0.726–0.811), outperforming TyG-WC and TyG-BMI (both p<0.05).
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
Clinicians may consider TyG-WHtR as an early risk-stratification tool in post-PCI AMI patients, particularly for identifying those at HF risk. However, prospective validation and comparison with established HF risk scores in independent cohorts is needed before incorporation into routine prognostic algorithms.
Single-centre retrospective study with a clear independent association and moderate discrimination (AUC 0.769) for a clinically relevant outcome, but limited by retrospective design, lack of external validation, and surrogate endpoint focus (HF occurrence rather than mortality or major morbidity).
As stated by the source record.
Quoted from the source exactly as published.
Clinicians may consider TyG-WHtR as an early risk-stratification tool in post-PCI AMI patients, particularly for identifying those at HF risk. However, prospective validation and comparison with established HF risk scores in independent cohorts is needed before incorporation into routine prognostic algorithms.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
Background Heart failure (HF) after acute myocardial infarction (AMI) remains a major clinical challenge. The triglyceride glucose-waist-to-height ratio (TyG-WHtR) integrates metabolic and obesity indices, yet its prognostic value for AMI-HF is unclear. Methods This retrospective study enrolled 738 AMI patients undergoing PCI from January 2019 to June 2024. Baseline TyG-WHtR was calculated pre-discharge. The primary outcome was HF occurrence within 1-year follow-up. Multivariate logistic regression and restricted cubic splines (RCS) assessed associations. Receiver operating characteristic (ROC) curves and DeLong tests compared TyG-WHtR against the GRACE score and other metabolic indices. Subgroup analyses were performed based on AMI-to-PCI time and ESC-defined HF classifications. Results A total of 136 patients (18.4%) developed HF. TyG-WHtR was an independent predictor of AMI-HF (adjusted OR = 1.192, 95% CI: 1.021∼1.392, p = 0.026), persisting after adjusting for the post-PCI GRACE score. RCS revealed a positive nonlinear dose-response relationship (p-nonlinear=0.034). TyG-WHtR demonstrated good discrimination (AUC=0.769, 95% CI: 0.726∼0.811), outperforming TyG-WC and TyG-BMI (both p 0.05). Notably, TyG-WHtR showed superior predictive value in HFpEF (AUC=0.815) compared to GRACE (AUC=0.761, p = 0.012), whereas GRACE performed better in HFrEF. The predictive value was consistent across AMI-to-PCI time strata (p-interaction=0.584). Baseline TyG-WHtR correlated inversely with 1-year LVEF (r = −0.327, p 0.001) in HF patients. Conclusion TyG-WHtR is an independent risk factor for 1-year AMI-HF, particularly in HFpEF phenotypes. It provides incremental prognostic value beyond the GRACE score and may guide early risk stratification in post-PCI AMI patients.
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