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Life sciences · Preprint
arXiv · October 3, 2026
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Calibrating microscopic traffic models for digital twins is an expensive black-box optimization problem: tuning car-following and lane-changing parameters requires a full simulation run, affording only a tight budget per recalibration window. Matching raw trajectories yields a rugged objective that sparse surrogates cannot learn, reducing sequential acquisition to near-random probing. We present FLAT, which couples what to optimize with where to sample next. An eight-dimensional behavioral fingerprint smooths the parameter-error landscape, making the objective learnable from a few dozen samples; annealed lower-confidence-bound (LCB) acquisition then spends each remaining run where it most reduces error. The surrogate, interchangeable among a Gaussian process (GP), random forest (RF), or multi-layer-perceptron (MLP) ensemble, plugs into the same LCB loop. Across six heterogeneous real-world scenes, FLAT-GP achieves the lowest scene-averaged behavioral error, winning 6/6 scenes against SPSA, GA, and CMA-ES and 5/6 against TPE under the matched budget. Some baselines need up to 4.4 times more simulations to match. Ablations show objective choice shifts final behavioral error by 81% on average, removing sequential LCB raises the six-scene mean by 20%, and surrogate choice shifts it by at most 4.2%, confirming gains trace to objective geometry and sequential allocation rather than surrogate capacity.