Life sciences · Preprint
arXiv · September 28, 2026
No summary has been generated for this record yet. What follows is drawn from its source metadata only.
Preprint.
No findings were extractable from the material analysed.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
This record has not been graded across any dimension yet. Treat the label above as provisional and read the source.
What is missing. This record has no bottom line, key findings, reported figures, evidence dimensions. That is a gap in the analysis, not a judgement about the study.
Interior-point methods (IPMs) are among the most widely used algorithms for constrained optimization, yet their Newton-based search directions require costly second-order information and large linear-system solves. Learning to optimize offers cheaper updates learned from data, but the singular behavior of logarithmic barriers near constraint boundaries makes IPMs highly sensitive to perturbations, complicating both warm starting and learning reliable updates. We introduce pdLIP, an IPM for smooth nonlinear programs that integrates learned preconditioning with pdProj, an all-shifted primal-dual projected-search IPM. A shared coordinate-wise recurrent network predicts a positive diagonal preconditioner that scales the right-hand side of the reduced Newton system for the primal step, and the remaining slack and multiplier directions are recovered analytically. The learned iterations avoid Hessian evaluations and Newton-system solves, using only first-order and coordinate-wise operations amenable to GPU parallelization. Training is self-supervised, with a loss based on a penalty-barrier merit function and the residual of perturbed optimality conditions, requiring neither target directions nor precomputed solutions. Primal and dual shifts mitigate the barrier's sensitivity to perturbations near constraint boundaries, enabling effective warm starting. Across four classes of 200-dimensional convex and nonconvex constrained problems, pdLIP warm starts reduce pdProj refinement iterations by 63-67% compared with cold starts at the same KKT residual tolerance of $10^{-8}$, with negligible warm-start generation cost relative to the subsequent pdProj solve. Improvements persist on box-constrained QPs with 1000 variables and extend to applications including portfolio optimization, support vector machines, and a nonlinear control example.