Life sciences · Interventional Study
ClinicalTrials.gov · November 9, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT07926542). This is a study registration, not published results. Lead sponsor: Centro Hospitalar de Lisboa Central. Recruitment status: COMPLETED. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 40 participants (ACTUAL). Conditions: Conscious Sedation, Lung Neoplasms, Lymphadenopathy (Mediastinal). Interventions: DRUG: Dexmedetomidine; DRUG: Midazolam; DRUG: fentanyl. Primary outcome measures: Patient Discomfort Assessed by Visual Analogue Scale , Baseline/Day 1; Physician-Rated Procedural Difficulty Assessed by Visual Analogue Scale , Baseline/Day 1. Brief summary: Endobronchial ultrasound (EBUS) is commonly performed under moderate sedation with midazolam and fentanyl, but patients may still experience discomfort and procedures can be technically demanding. Dexmedetomidine is a sedative that causes little respiratory depression. This randomized trial evaluated whether adding a continuous dexmedetomidine infusion to standard midazolam-fentanyl sedation reduces patient discomfort and procedural difficulty during EBUS, compared with midazolam-fentanyl alone.