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Life sciences · Interventional Study
ClinicalTrials.gov · October 22, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT07756112). This is a study registration, not published results. Lead sponsor: University of Iowa. Recruitment status: RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 104 participants (ESTIMATED). Conditions: Wound Healing. Interventions: PROCEDURE: Collagen Plug (standard of care); PROCEDURE: Platelet-Rich Fibrin Clot. Primary outcome measures: Change in Growth Factor Quality between Normal and Obese Patients who received either Platelet-Rich Fibrin Clot or Collagen Plug at 30 days after baseline , Baseline, 30 days after baseline. Brief summary: Healing after dental surgery can vary from person to person. This study is being done to understand how body weight (obesity vs. normal weight) may affect healing after tissue is removed from the roof of the mouth during a gum graft procedure. The study will also evaluate whether a healing material made from a participant's own blood, called platelet-rich fibrin (PRF), is comparable in quantity and quality to the standard-of-care collagen plug. First, participants will be classified into obese or normal weight groups. Next, participants will be randomized to receive either collagen plug or platelet-rich fibrin clot during their surgical procedure Then, participants will return for 4 visits up to 30 days from the surgery visit.