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Life sciences · Observational Study
ClinicalTrials.gov · September 24, 2026
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Observational Study.
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Registry record from ClinicalTrials.gov (NCT07838766). This is a study registration, not published results. Lead sponsor: Chang Gung Memorial Hospital. Recruitment status: NOT_YET_RECRUITING. Study type: OBSERVATIONAL. Enrollment: 800 participants (ESTIMATED). Conditions: Outpatients With Chronic Heart Failure, Heart Failure Chronic. Primary outcome measures: Recurrent worsening heart failure (HF) event burden , within 36 months after enrollment. Brief summary: Heart failure is a complex clinical syndrome with high hospitalization rates and high mortality risks. While NT-proBNP is widely used in clinical practice to assist in diagnosis and assessment, its ability to detect prognosis in heart failure remains insufficient. Recent scientific research has found that phenylalanine in the blood and its endogenous toxic substance phenylpyruvate are closely related to impaired energy synthesis in heart muscle cells, making them highly promising next-generation long-term biomarkers. Our research team has previously developed a "risk score" prediction model that combines phenylpyruvate levels in the blood with clinical data; this project aims to further confirm its clinical value. Therefore, we cordially invite heart failure patients who are being followed up in the cardiology outpatient clinic to have their "phenylalanine" and "phenylpyruvic acid" concentrations measured in a small amount of blood. This data, combined with clinical data, will be used to calculate a "Risk Score" to identify high-risk heart failure patients earlier.